Clinical Significance

Definition

Health Economics

  • A treatment effect that is large enough to be of practical importance to patients and clinicians. This is not the same as statistical significance or cost-effectiveness. Its assessment takes account of factors like the size of any outcome, the importance of the outcome to the patient or clinician, the severity of the condition being treated and the side-effects of the treatment. Cost is sometimes also taken into account. It evidently requires a somewhat subjective (but experienced) judgment.
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