Dose-Response Curve


Health Economics

  • This is a diagram in which the x -axis plots concentration of a drug (or some other exposure variable, harmful or beneficial) and the y -axis plots responses such as secretion of a hormone, heartbeat or health outcome. It is similar to the diagrammatic representation of a production function where there is a single variable input and a single output. The standard dose-response curve has four parameter s: the baseline response, the maximum response, the slope and the exposure concentration that provokes a response halfway between baseline and maximum. In meta-analyses, dose-response can be investigated using meta-regression. A typical curve is initially convex (from above), followed by a concave section, with a point of inflexion between.